Comparative evaluation of antibody response in rabbits vaccinated with toxoid, alum precipitated and alum precipitated oil adjuvant enterotoxaemia vaccines

Comparative evaluation of antibody response in rabbits vaccinated with toxoid

Aim: To compare the newly formulated enterotoxaemia vaccine having oil and alum adjuvants, with presently available toxoid and alum precipitated vaccines. Materials and Methods: Three types of enterotoxaemia vaccines, namely toxoid (TV), alum precipitated (APV) and alum precipitated oil adjuvant vaccine (AOV) were prepared using a highly toxigenic strain of Clostridium perfringens type D procur...

Preparation and Evaluation of Alum Precipitated and Oil-based Haemorrhagic Septicaemia Vaccines

Pasteurella multocida (Robert type-1) was grown on tryptose sucrose yeast (TSY) broth in a fermenter. A sterilised air was provided that potentiated the density of the culture (5 x 10 organisms/ml). The culture was inactivated with formalin (0.5% ). The alum precipitated and oil based haemorrhagic septicaemia vaccines (APHSV and OBHSV) were prepared and their efficacies were evaluated in rabbit...

Studies on Tetanus Toxoid: III. Antitoxic Response in Guinea Pigs Immunized with Tetanus Alum-precipitated Toxoid Followed by Tetanus Spores.

When an individual has been given one or more injections of tetanus toxoid and, at a later date, is injured and possibly infected with Clostridium tetani, what further precautions should be taken: (1) Administer antitoxin? (2) Give another injection of tetanus toxoid to accelerate the production of antitoxin? (3) Give no further treatment, depending on his present immunity to take care of the i...

Role of alum as adjuvant in Clostridial vaccines

Research Communication Effective Immunization of Lambs against Enterotoxaemia

CAMERON, C. M., 1980. Effective immunization of lambs against enterotoxaemia. Onderstepoort Journal of Veterinary Research, 47, 287-289 (1980). In contrast to adult sheep, 2to 3-month-old lambs do not respond well to a single injection of Clostridium perfringens Type D oil adjuvant epsilon toxoid. This unresponsiveness can be overcome, however, by administering 2 injections of oil adjuvant vacc...